A recent study led by George Feldman, PhD, DMD, assistant professor of Orthopaedics at Thomas Jefferson University, reveals a genetic mutation that may detect susceptibility for developmental dysplasia of the hip (DDH).
Dr. Feldman and his team of researchers studied a four-generation family in Utah with a history of developmental dysplasia of the hip (DDH). They found 11 family members had at least three signs of the condition and 13 members had one or two signs and a questionable diagnosis.
DNA analysis revealed a mutation co-inherited by all affected family members. This variant is a genetic mutation on chromosome 3 in a chemokine receptor which functions as a receptor for a chemical messenger that may affect the maturation of cartilage forming cells, possibly delaying their development.
Even some of those who had fewer signs of the disease were also found to have the disease variant.
The researchers hope these findings will lead them to a genetic test that will allow them to detect susceptibility for developmental dysplasia of the hip (DDH) early.
Orthopedics Today is covering this research.
Read “Large Multi-Generational Family Helps Unlock Genetic Secrets To Developmental Dysplasia Of The Hip” for more information.